D2K, PEALS, Newcastle University

1958 Birth Cohort

Introduction to 1958 Birth Cohort

1958 birth cohort logo (NCDS)

The 1958 Birth Cohort, or National Child Development Study, makes resources available to research scientists (biomedical, psychosocial, educational or ethico-legal) from anywhere in the world that have successfully applied to the METADAC committee or the Consortium Data Access Committee (CDAC). Cell-line DNA, whole-blood DNA, plasma, serum and saliva samples are held by this study and can be accessed via METADAC in accordance with the samples strategy.

The resource is used widely for:

– research in genetic and genomic epidemiology, in particular as a platform for genetic association studies.
– providing a source of subjects that have been well characterised (phenotyped) for a variety of quantitative complex traits and have also been assessed for a variety of socio-demographic, socio-economic and life style variables that are outcomes in their own right, and may be important determinants in relevant causal pathways leading to disease
– providing a source of ‘cases’ and ‘controls’ for common binary traits
– providing a geographically representative sample of British people (of primarily European origin) that represents the premier source of national controls that can be used in a wide variety of genetic case-control studies

METADAC reviews all applications for access to bio samples, exome sequence data, or phenotype (survey) data linked with genetic data or biological samples. Please use the METADAC application form and guidance.

For more information on the genetic data and samples available from 1958BC, please see 58 FORWARDS web-page. If you are applying for samples, a Material Transfer Agreement (MTA) must be signed. It may be worth checking the example MTA with your legal team in advance.